TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury

TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury

During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins, all of which affect recovery and compromise neuro...

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Bibliographic Details
Main Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
multiple sclerosis (MS)
TMEM106B
myelin oligodendrocyte glycoprotein (MOG)-induced EAE
demyelination
lipids
Online Access:https://www.mdpi.com/2073-4409/12/13/1734

Internet

https://www.mdpi.com/2073-4409/12/13/1734

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