Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice

Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which non-cell-autonomous processes have been proposed as its cause. Non-neuronal cells that constitute the environment around motor neurons are known to mediate the pathogenesis of ALS. Perivascular macrophages (PVM) are immune...

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Bibliographic Details
Main Authors: Kazuki Adachi, Kota Miyata, Yukino Chida, Mikako Hirose, Yuta Morisaki, Koji Yamanaka, Hidemi Misawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
SOD1G93A mouse
perivascular macrophage
clodronate liposomes
blood-spinal cord barrier
extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1291673/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1291673/full

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