Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

Strong innate and adaptive immune responses are paramount in combating viral infections. Dendritic cells (DCs) detect viral infections via cytosolic RIG-I like receptors (RLRs) RIG-I and MDA5 leading to MAVS-induced immunity. The DEAD-box RNA helicase DDX3 senses abortive human immunodeficiency viru...

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Bibliographic Details
Main Authors: Melissa Stunnenberg, Joris K. Sprokholt, John L. van Hamme, Tanja M. Kaptein, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
abortive HIV-1 RNA
type I IFN
viral sensing
DDX3
pattern recognition receptor
dendritic cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00008/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00008/full

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