Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease

Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease

Diarrhea-positive hemolytic-uremic syndrome (HUS) is a renal disorder that results from infections with Shiga-toxin (Stx)-producing Escherichia coli. The aim of this study was to establish well-defined refined murine models of HUS that can serve as preclinical tools to elucidate molecular mechanisms...

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Bibliographic Details
Main Authors: Sophie Dennhardt, Wiebke Pirschel, Bianka Wissuwa, Christoph Daniel, Florian Gunzer, Sandro Lindig, Anna Medyukhina, Michael Kiehntopf, Wolfram W. Rudolph, Peter F. Zipfel, Matthias Gunzer, Marc Thilo Figge, Kerstin Amann, Sina M. Coldewey
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
hemolytic-uremic syndrome
Shiga toxin
enterohemorrhagic E. coli
Escherichia coli
acute kidney injury
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01459/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01459/full

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