The malignant transformation potential of the oncogene STYK1/NOK at early lymphocyte development in transgenic mice

The malignant transformation potential of the oncogene STYK1/NOK at early lymphocyte development in transgenic mice

B-cell Chronic Lymphocytic Leukemia (B-CLL) is a malignancy caused by the clonal expansion of mature B lymphocytes bearing a CD5+CD19+ (B1) phenotype. However, the origin of B-CLL remains controversial. We showed previously that STYK1/NOK transgenic mice develop a CLL-like disease. Using this model...

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Bibliographic Details
Main Authors: Yin Yang, Li Liu, Haley O. Tucker
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
CLL
STYK1/NOK
Lymphadenectasis
HSC
B lymphocyte
B1 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824000736

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http://www.sciencedirect.com/science/article/pii/S2405580824000736

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