A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice

A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice

Atherosclerosis is a chronic inflammatory disease caused by deposition of oxidative low-density lipoprotein (LDL) in the arterial intima which triggers the innate immune response through myeloid cells such as macrophages. Regulatory T cells (Tregs) play an important role in controlling the progressi...

Full description

Bibliographic Details
Main Authors: Xiaoyun Zhu, Qiongzhen Li, Varghese George, Catherine Spanoudis, Crystal Gilkes, Niraj Shrestha, Bai Liu, Lin Kong, Lijing You, Christian Echeverri, Liying Li, Zheng Wang, Pallavi Chaturvedi, Gabriela J. Muniz, Jack O. Egan, Peter R. Rhode, Hing C. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
IL-2
IL-2-based fusion molecule
Tregs
M2 macrophages
myeloid-derived suppressor cells
inflammatory diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114802/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114802/full

Similar Items