Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages

Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages

The host immune system plays a pivotal role in the containment of Mycobacterium tuberculosis (Mtb) infection, and host-directed therapy (HDT) is emerging as an effective strategy to treat tuberculosis (TB), especially drug-resistant TB. Previous studies revealed that expression of sirtuin 7 (SIRT7),...

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Bibliographic Details
Main Authors: Su Zhang, Yaya Liu, Xuefeng Zhou, Min Ou, Guohui Xiao, Fang Li, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
SIRT7
nitric oxide
apoptosis
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.779235/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.779235/full

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