Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

Summary: Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the major facilitator superfamily that constitute the main route of entry for a wide range of dietary peptides and orally administrated peptidomimetic drugs. Given their clinical and pathophysiological relevan...

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Bibliographic Details
Main Authors: Vadim Kotov, Maxime Killer, Katharina E.J. Jungnickel, Jian Lei, Giada Finocchio, Josi Steinke, Kim Bartels, Jan Strauss, Florine Dupeux, Anne-Sophie Humm, Irina Cornaciu, José A. Márquez, Els Pardon, Jan Steyaert, Christian Löw
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008422

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http://www.sciencedirect.com/science/article/pii/S2211124723008422

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