GLP-2 Prevents Neuronal and Glial Changes in the Distal Colon of Mice Chronically Treated with Cisplatin

GLP-2 Prevents Neuronal and Glial Changes in the Distal Colon of Mice Chronically Treated with Cisplatin

Cisplatin is a chemotherapeutic agent widely used for the treatment of solid cancers. Its administration is commonly associated with acute and chronic gastrointestinal dysfunctions, likely related to mucosal and enteric nervous system (ENS) injuries, respectively. Glucagon-like peptide-2 (GLP-2) is...

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Bibliographic Details
Main Authors: Patrizia Nardini, Alessandro Pini, Anne Bessard, Emilie Duchalais, Elena Niccolai, Michel Neunlist, Maria Giuliana Vannucchi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
antineoplastic drug
pleiotropic intestinal hormone
myenteric plexus
colonic mucosal layer
neuronal nitric oxide synthase (nNOS)
choline acetyltransferase (ChAT)
Online Access:https://www.mdpi.com/1422-0067/21/22/8875

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https://www.mdpi.com/1422-0067/21/22/8875

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