Integrated Transcriptome and Proteome Analyses Reveal the Regulatory Role of miR-146a in Human Limbal Epithelium via Notch Signaling

Integrated Transcriptome and Proteome Analyses Reveal the Regulatory Role of miR-146a in Human Limbal Epithelium via Notch Signaling

MiR-146a is upregulated in the stem cell-enriched limbal region vs. central human cornea and can mediate corneal epithelial wound healing. The aim of this study was to identify miR-146a targets in human primary limbal epithelial cells (LECs) using genomic and proteomic analyses. RNA-seq combined wit...

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Bibliographic Details
Main Authors: Adam J. Poe, Mangesh Kulkarni, Aleksandra Leszczynska, Jie Tang, Ruchi Shah, Yasaman Jami-Alahmadi, Jason Wang, Andrei A. Kramerov, James Wohlschlegel, Vasu Punj, Alexander V. Ljubimov, Mehrnoosh Saghizadeh
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
cornea
miRNA
miR-146a
Notch
Numb
limbal stem cells
Online Access:https://www.mdpi.com/2073-4409/9/10/2175

Internet

https://www.mdpi.com/2073-4409/9/10/2175

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