DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance.

DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance.

Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to current chemotherapy regimens, in part due to alterations in the p53 tumor suppressor pathway. p53 homolog p63 is a transcription factor essential for the development and differentiation of epithelial surfaces. However its function in ca...

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Bibliographic Details
Main Authors: Alexey V Danilov, Divas Neupane, Archana Sidalaghatta Nagaraja, Elena V Feofanova, Leigh Ann Humphries, James DiRenzo, Murray Korc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203907?pdf=render

Internet

http://europepmc.org/articles/PMC3203907?pdf=render

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