Development of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum

Development of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum

Heme is an important tetrapyrrole compound, and has been widely applied in food and medicine industries. Although microbial production of heme has been developed with metabolic engineering strategies during the past 20 years, the production levels are relatively low due to the multistep enzymatic pr...

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Bibliographic Details
Main Authors: Yingyu Zhou, Jiuzhou Chen, Wei Pu, Ningyun Cai, Bin Che, Jinxing Yang, Mengmeng Wang, Shasha Zhong, Xingtao Zuo, Depei Wang, Yu Wang, Ping Zheng, Jibin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
heme
growth-coupled
coproporphyrin ferrochelatase
directed evolution
electron transport system
detoxification
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1236118/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1236118/full

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