Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α‐ and β‐Myosin Heavy Chain Isoforms

Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α‐ and β‐Myosin Heavy Chain Isoforms

BackgroundWe hypothesized that the functional effects of R206L—a rat analog of the dilated cardiomyopathy (DCM) mutation R205L in human cardiac troponin T (TnT)—were differently modulated by myosin heavy chain (MHC) isoforms and T204E, a protein kinase C (PKC) phosphomimic of TnT. Our hypothesis was...

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Bibliographic Details
Main Authors: John Jeshurun Michael, Murali Chandra
Format: Article
Language:English
Published: Wiley 2016-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
dilated cardiomyopathy
myosin heavy chain
post‐translational modification
protein kinase C
troponin T
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002777

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.115.002777

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