Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase–RNA complexes

Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase–RNA complexes

RNases are varied in the RNA structures and sequences they target for cleavage and are an important type of enzyme in cells. Despite the numerous examples of RNases known, and of those with determined three-dimensional structures, relatively few examples exist with the RNase bound to intact cognate...

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Bibliographic Details
Main Authors: Seth P. Jones, Christian Goossen, Sean D. Lewis, Annie M. Delaney, Michael L. Gleghorn
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Structural Biology: X
Subjects:
RNase–RNA complex
Pre-cleavage
Scissile-phosphate
Structure determination
Enzymatic inhibition
Nucleic acid recognition
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152422000071

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http://www.sciencedirect.com/science/article/pii/S2590152422000071

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