5-Aza-2′-Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III Expression in TGF-β1-Treated Equine Endometrial Fibroblasts

5-Aza-2′-Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III Expression in TGF-β1-Treated Equine Endometrial Fibroblasts

Endometrosis negatively affects endometrial function and fertility in mares, due to excessive deposition of type I (COL1) and type III (COL3) collagens. The pro-fibrotic transforming growth factor (TGF-β1) induces myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expressi...

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Bibliographic Details
Main Authors: Joana Alpoim-Moreira, Anna Szóstek-Mioduchowska, Magda Słyszewska, Maria Rosa Rebordão, Dariusz J. Skarzynski, Graça Ferreira-Dias
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Animals
Subjects:
endometrosis
mare
collagen
epigenetics
DNMTs
fibroblasts
Online Access:https://www.mdpi.com/2076-2615/13/7/1212

Internet

https://www.mdpi.com/2076-2615/13/7/1212

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