Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is the major dose-limiting side effect of many commonly used chemotherapeutic agents, including paclitaxel. Currently, there are no neuroprotective or effective symptomatic treatments for CIPN. Lack of understanding of the in vivo mechanisms of CIPN...

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Bibliographic Details
Main Authors: Jennifer M. Brazill, Beverley Cruz, Yi Zhu, R. Grace Zhai
Format: Article
Language:English
Published: The Company of Biologists 2018-06-01
Series:Disease Models & Mechanisms
Subjects:
Paclitaxel
Chemotherapy
Neuropathy
Microtubules
Nmnat
Neuroprotection
Online Access:http://dmm.biologists.org/content/11/6/dmm032938

Internet

http://dmm.biologists.org/content/11/6/dmm032938

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