Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release

Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release

Chronic stress is a critical risk factor for developing depression, which can impair cognitive function. However, the underlying mechanisms involved in chronic stress-induced cognitive deficits remain unclear. Emerging evidence suggests that collapsin response mediator proteins (CRMPs) are implicate...

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Bibliographic Details
Main Authors: Yu-Fen Lin, Ching-An Chen, Fang-Yu Hsu, Ya-Hsin Hsiao
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
chronic unpredictable stress
cognitive deficits
collapsin response mediator proteins
AMPA receptor trafficking
synaptic atrophy
Online Access:https://www.mdpi.com/1422-0067/24/5/4898

Internet

https://www.mdpi.com/1422-0067/24/5/4898

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