Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency

Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency

Summary: We used the recombinant trimeric spike (S) glycoprotein in the prefusion conformation to immunize horses for the production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:106, and the neutralizing antibody titer against authentic virus (WT)...

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Bibliographic Details
Main Authors: Luis Eduardo R. Cunha, Adilson A. Stolet, Marcelo A. Strauch, Victor A.R. Pereira, Carlos H. Dumard, Andre M.O. Gomes, Fábio L. Monteiro, Luiza M. Higa, Patrícia N.C. Souza, Juliana G. Fonseca, Francisco E. Pontes, Leonardo G.R. Meirelles, José W.M. Albuquerque, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Tulio M. Lima, Renata G.F. Alvim, Federico F. Marsili, Marcella Moreira Caldeira, Russolina B. Zingali, Guilherme A.P. de Oliveira, Thiago M.L. Souza, Alexandre S. Silva, Rodrigo Muller, Daniela del Rosário Flores Rodrigues, Luciana Jesus da Costa, Arthur Daniel R. Alves, Marcelo Alves Pinto, Andréa C. Oliveira, Herbert L.M. Guedes, Amilcar Tanuri, Leda R. Castilho, Jerson L. Silva
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Immunology
Equine immunology
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012840

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http://www.sciencedirect.com/science/article/pii/S2589004221012840

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