Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay

Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay

Lipophosphoglycan (LPG) is the major surface glycoconjugate of metacyclic Leishmania promastigotes and is associated with virulence in various species of this parasite. Here, we generated a LPG-deficient mutant of Leishmania infantum, the foremost etiologic agent of visceral leishmaniasis in Brazil....

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Bibliographic Details
Main Authors: Milena Lázaro-Souza, Christine Matte, Jonilson B. Lima, Guillermo Arango Duque, Graziele Quintela-Carvalho, Áislan de Carvalho Vivarini, Sara Moura-Pontes, Cláudio P. Figueira, Flávio H. Jesus-Santos, Ulisses Gazos Lopes, Leonardo P. Farias, Théo Araújo-Santos, Albert Descoteaux, Valéria M. Borges
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
Lipophosphoglycan
Leishmania infantum
gene targeting
lipid droplets
macrophage
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00626/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00626/full

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