Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection

Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection

IntroductionStreptococcus pyogenes is a Gram-positive pathogen that causes a significant global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe invasive streptococcal diseases. Previous studies have shown that IL-17 deficiency in mice (IL-17−/−) can reduce S. pyo...

Full description

Bibliographic Details
Main Authors: Jamie-Lee Mills, Ailin Lepletier, Victoria Ozberk, Jessica Dooley, Jacqualine Kaden, Ainslie Calcutt, Yongbao Huo, Allan Hicks, Ali Zaid, Michael F. Good, Manisha Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
S. pyogenes
IL-17
invasive streptococcal infection
mucosal infection
natural immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351777/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351777/full

Similar Items