Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo

Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo

Abstract Background Ways to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of perivascular cell signalling could provide unparalleled insight as these cells impact vascular stability and functionality of the neurovascular un...

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Bibliographic Details
Main Authors: Julia Baumann, Chih-Chieh Tsao, Shalmali Patkar, Sheng-Fu Huang, Simona Francia, Synnøve Norvoll Magnussen, Max Gassmann, Johannes Vogel, Christina Köster-Hegmann, Omolara O. Ogunshola
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Neurovascular unit
Perivascular signaling
Vascular remodeling
Cerebral edema
Tight junctions
Online Access:https://doi.org/10.1186/s12987-021-00302-y

Internet

https://doi.org/10.1186/s12987-021-00302-y

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