Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)<sub>2</sub>-NH<sub>2</sub> and Their Conjugates Containing Unnatural Amino Acids

Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)<sub>2</sub>-NH<sub>2</sub> and Their Conjugates Containing Unnatural Amino Acids

(1) Background: (KLAKLAK)<sub>2</sub> is a representative of the antimicrobial peptide group which also shows good anticancer properties. (2) Methods: Herein, we report synthesis using SPPS and characterization by HPLC/MS of a series of shortened analogues of (KLAKLAK)<sub>2</su...

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Bibliographic Details
Main Authors: Sirine Jaber, Ivan Iliev, Tsvetelina Angelova, Veronica Nemska, Inna Sulikovska, Emilia Naydenova, Nelly Georgieva, Ivan Givechev, Ivo Grabchev, Dancho Danalev
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
(KLAKLAK)<sub>2</sub>-NH<sub>2</sub>
anticancer peptides
1,8-naphthalimide
caffeic acid
unnatural amino acids
antimicrobial activity
Online Access:https://www.mdpi.com/1420-3049/26/4/898

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https://www.mdpi.com/1420-3049/26/4/898

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