Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To understand the physiological significance of HS-induced...

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Bibliographic Details
Main Authors: Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
heparan sulfate
RAGE
inflammation
osteoclast
oligomerization
Online Access:https://elifesciences.org/articles/71403

Internet

https://elifesciences.org/articles/71403

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