The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease

The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease

Organic cation transporter 2 (OCT2), encoded by the SLC22A2 gene, is the main cation transporter on the basolateral membrane of proximal tubular cells. OCT2 facilitates the entry step of the vectorial transport of most cations from the peritubular space into the urine. OCT2 downregulation in kidney...

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Bibliographic Details
Main Authors: Chao Han, Juan Zheng, Fengyi Wang, Qingyang Lu, Qingfa Chen, Ankang Hu, Michele Visentin, Gerd A. Kullak-Ublick, Zhibo Gai, Lei Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Medicine
Subjects:
chronic kidney disease
inflammation
NF-kB
organic cation transporter
TNF-α
tubular secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.800421/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.800421/full

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