Sigma-1 receptor knockout disturbs gut microbiota, remodels serum metabolome, and exacerbates isoprenaline-induced heart failure

Sigma-1 receptor knockout disturbs gut microbiota, remodels serum metabolome, and exacerbates isoprenaline-induced heart failure

IntroductionHeart failure (HF) is usually the end stage of the continuum of various cardiovascular diseases. However, the mechanism underlying the progression and development of HF remains poorly understood. The sigma-1 receptor (Sigmar1) is a non-opioid transmembrane receptor implicated in many dis...

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Bibliographic Details
Main Authors: Jian-Zheng Yang, Kai-Kai Zhang, Hong-Wu Shen, Yi Liu, Xiu-Wen Li, Li-Jian Chen, Jia-Li Liu, Jia-Hao Li, Dong Zhao, Qi Wang, Chu-Song Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Microbiology
Subjects:
heart failure
sigma-1 receptor
gut microbiota
untargeted metabolomics
transcriptomics
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1255971/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1255971/full

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