Whole Transcriptome Mapping Identifies an Immune- and Metabolism-Related Non-coding RNA Landscape Remodeled by Mechanical Stress in IL-1β-Induced Rat OA-like Chondrocytes

Whole Transcriptome Mapping Identifies an Immune- and Metabolism-Related Non-coding RNA Landscape Remodeled by Mechanical Stress in IL-1β-Induced Rat OA-like Chondrocytes

Background: Osteoarthritis (OA) is a common degenerative joint disease. The aims of this study are to explore the effects of mechanical stress on whole transcriptome landscape and to identify a non-coding transcriptome signature of mechanical stress.Methods: Next-generation RNA sequencing (RNA-seq)...

Full description

Bibliographic Details
Main Authors: Jiaming Zhang, Xiaoxia Hao, Ruimin Chi, Jiawei Liu, Xingru Shang, Xiaofeng Deng, Jun Qi, Tao Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
osteoarthritis
chondrocyte biology
mechanical stress
transcriptome
non-coding RNA
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.821508/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.821508/full

Similar Items