The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.

The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.

Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional regulation, is hijacked by diverse viruses to facilitate viral replication. However, its regulatory effect in antiviral innate immunity remains unclear. We found that DDX5 interacts with the N6-methyladenosine (m6A) w...

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Bibliographic Details
Main Authors: Jian Xu, Yunhong Cai, ZhenBang Ma, Bo Jiang, Wenxiao Liu, Jing Cheng, Nannan Guo, Zishu Wang, Joshua E Sealy, Cuiping Song, Xiaojia Wang, Yongqing Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009530

Internet

https://doi.org/10.1371/journal.ppat.1009530

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