MSCs overexpressing GDNF restores brain structure and neurological function in rats with intracerebral hemorrhage

MSCs overexpressing GDNF restores brain structure and neurological function in rats with intracerebral hemorrhage

Abstract Mesenchymal stem cells (MSCs) have been applied in transplantation to treat intracerebral hemorrhage (ICH) but with limited efficacy. Accumulated evidence has shown that glial cell-derived neurotrophic factor (GDNF) plays a crucial part in neuronal protection and functional recovery of the...

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Bibliographic Details
Main Authors: Xiaoqian Jiang, Ling Zhou, Zihuan Sun, Bingqing Xie, Heng Lin, Xiaoqing Gao, Li Deng, Chaoxian Yang
Format: Article
Language:English
Published: Springer 2023-11-01
Series:Molecular Biomedicine
Subjects:
Intracerebral hemorrhage
Mesenchymal stem cells
Glial cell-derived neurotrophic factor
Synaptic plasticity
Neurological recovery
Online Access:https://doi.org/10.1186/s43556-023-00159-7

Internet

https://doi.org/10.1186/s43556-023-00159-7

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