Protein interactors of 3-O sulfated heparan sulfates in human MCI and age-matched control cerebrospinal fluid

Abstract Heparan sulfates (HS) proteoglycans are commonly found on the cell surface and mediate many processes. Binding of HS ligands is determined by the sulfation code on the HS chain that can be N-/2-O/6-O- or 3-O-sulfated, generating heterogenous sulfation patterns. 3-O sulfated HS (3S-HS) play...

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Bibliographic Details
Main Authors: Andreia Ferreira, Evy Timmerman, An Staes, Marnik Vuylsteke, Louis De Muynck, Kris Gevaert
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Data
Online Access:https://doi.org/10.1038/s41597-023-02009-1