Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study

Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study

Late-life depression (LLD) is a risk factor for age-dependent cognitive deterioration. Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To examine the LC norepinephrine system in vivo, we acquired neuromelanin-sensitive MRI (NM-MRI) in a sample of 48 participant...

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Bibliographic Details
Main Authors: Navona Calarco, Clifford M. Cassidy, Ben Selby, Colin Hawco, Aristotle N. Voineskos, Breno S. Diniz, Yuliya S. Nikolova
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:NeuroImage: Clinical
Subjects:
Major Depressive Disorder
Late-life
Neuromelanin-sensitive imaging
Locus coeruleus
Canonical correlation analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158222002479

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http://www.sciencedirect.com/science/article/pii/S2213158222002479

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