Structural modeling of hERG channel–drug interactions using Rosetta

Structural modeling of hERG channel–drug interactions using Rosetta

The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. Genetic hERG mutations and blockage of the channel pore by drugs can cause long QT syndrome, which...

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Bibliographic Details
Main Authors: Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kazuharu Furutani, Slava Bekker, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
hERG channel
potassium channel
state-dependent
drug block
Rosetta
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1244166/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1244166/full

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