cAMP‐Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease

cAMP‐Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease

Abstract Formation of biomolecular condensates by phase separation has recently emerged as a new principle for regulating gene expression in response to extracellular signaling. However, the molecular mechanisms underlying the coupling of signal transduction and gene activation through condensate fo...

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Bibliographic Details
Main Authors: Zeyun Mi, Yandong Song, Jiuchen Wang, Zhiheng Liu, Xinyi Cao, Lin Dang, Yumei Lu, Yongzhan Sun, Hui Xiong, Lirong Zhang, Yupeng Chen
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Advanced Science
Subjects:
ADPKD
cAMP
condensate
CRTC2
phase separation
P‐TEFb
Online Access:https://doi.org/10.1002/advs.202104578

Internet

https://doi.org/10.1002/advs.202104578

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