A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that can accumulate in the human body due to its long half-life. This substance has been associated with liver, pancreatic, testicular and breast cancers, liver steatosis and endocrine disruption. PFOA is a member of a large gro...

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Bibliographic Details
Main Authors: Arthur de Carvalho e Silva, George D. Loizou, Kevin McNally, Olivia Osborne, Claire Potter, David Gott, John K. Colbourne, Mark R. Viant
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Toxicology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2024.1368320/full