Is CD47 an innate immune checkpoint for tumor evasion?

Is CD47 an innate immune checkpoint for tumor evasion?

Abstract Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Various solid and hematologic cancers exploit CD47 expression in order to evade immunol...

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Bibliographic Details
Main Authors: Xiaojuan Liu, Hyunwoo Kwon, Zihai Li, Yang-xin Fu
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
CD47
SIRPα
“Don’t eat me” signal
Cancer immunotherapy
Chemotherapy
Clinical trial
Online Access:http://link.springer.com/article/10.1186/s13045-016-0381-z

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http://link.springer.com/article/10.1186/s13045-016-0381-z

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