Synthesis and Anticancer Activity of Hybrid Molecules Based on Lithocholic and (5<i>Z</i>,9<i>Z</i>)-Tetradeca-5,9-dienedioic Acids Linked via Mono(di,tri,tetra)ethylene Glycol and α,ω-Diaminoalkane Units

Synthesis and Anticancer Activity of Hybrid Molecules Based on Lithocholic and (5<i>Z</i>,9<i>Z</i>)-Tetradeca-5,9-dienedioic Acids Linked via Mono(di,tri,tetra)ethylene Glycol and α,ω-Diaminoalkane Units

For the first time, hybrid molecules were synthesized on the basis of lithocholic and (5<i>Z</i>,9<i>Z</i>)-1,14-tetradeca-5,9-dienedicarboxylic acids, obtained in two stages using the homo-cyclomagnesiation reaction of 2-(hepta-5,6-diene-1-yloxy)tetrahydro-2H-pyran at the ke...

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Bibliographic Details
Main Authors: Vladimir A. D’yakonov, Regina A. Tuktarova, Lilya U. Dzhemileva, Svetlana R. Ishmukhametova, Usein M. Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
lithocholic acid
cross-cyclomagnesiation
anticancer activity
5<i>Z</i>,9<i>Z</i>-dienoic acids
apoptosis
cell signaling
Online Access:https://www.mdpi.com/1424-8247/14/2/84

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https://www.mdpi.com/1424-8247/14/2/84

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