Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans

Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans

Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The current lack of an effective vaccine to simultaneously protect against the four serotypes of DENV in seronegative individuals is a major unmet medical need. Further, the immunological basis for protective immun...

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Bibliographic Details
Main Authors: Nancy Graham, Phil Eisenhauer, Sean A. Diehl, Kristen K. Pierce, Stephen S. Whitehead, Anna P. Durbin, Beth D. Kirkpatrick, Alessandro Sette, Daniela Weiskopf, Jonathan E. Boyson, Jason W. Botten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
dengue
vaccine
CD8
CD4
TEMRA
protective immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00479/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00479/full

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