A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus

A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus

ABSTRACTInvasive aspergillosis (IA) is a common and deadly mold infection in immunocompromised patients. As morbidity and mortality of IA are primarily driven by poor immune defense, adjunct immunotherapies, such as chimeric antigen receptor (CAR) T cells, are direly needed. Here, we propose a novel...

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Bibliographic Details
Main Authors: Pappanaicken R. Kumaresan, Sebastian Wurster, Karishma Bavisi, Thiago Aparecido da Silva, Paul Hauser, Jordan Kinnitt, Nathaniel D. Albert, Uddalak Bharadwaj, Sattva Neelapu, Dimitrios P. Kontoyiannis
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
immunotherapy
aspergillosis
CAR T cells
T lymphocytes
cytokines
mouse model
Online Access:https://journals.asm.org/doi/10.1128/mbio.03413-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03413-23

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