Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron Variant

Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron Variant

ABSTRACT The SARS-CoV-2 Omicron variant is characterized by substantial changes in the antigenic structure of the Spike (S) protein. Therefore, antibodies induced by primary Omicron infection lack neutralizing activity against earlier variants. In this study, we analyzed whether these antigenic chan...

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Bibliographic Details
Main Authors: David Niklas Springer, Thomas Perkmann, Claudia Maria Jani, Patrick Mucher, Katja Prüger, Rodrig Marculescu, Elisabeth Reuberger, Jeremy Vann Camp, Marianne Graninger, Christian Borsodi, Josef Deutsch, Oliver Lammel, Stephan Walter Aberle, Elisabeth Puchhammer-Stöckl, Helmuth Haslacher, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
Omicron
antibodies
neutralization
antibody assay
sensitivity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02129-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02129-22

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