Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2

Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2

The guanine exchange factor DOCK2 regulates the development of immunomodulatory function in human stromal cells (mesenchymal stem/progenitor cells (MSPC) and fibroblasts), as demonstrated in three models.

Bibliographic Details
Main Authors:	Cornelia Scharler, Rodolphe Poupardin, Patricia Ebner-Peking, Martin Wolf, Christina Schreck, Gabriele Brachtl, Andre Cronemberger Andrade, Linda Krisch, Laurence Daheron, Katharina Schallmoser, Karsten Jürchott, Judit Küchler, Harald Stachelscheid, Hans-Dieter Volk, Robert A. J. Oostendorp, Dirk Strunk
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-022-04078-1

Similar Items

Improving Human Induced Pluripotent Stem Cell-Derived Megakaryocyte Differentiation and Platelet Production
by: Linda Krisch, et al.
Published: (2021-07-01)

Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function
by: Gabriele Brachtl, et al.
Published: (2022-03-01)

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles
by: Heide-Marie Binder, et al.
Published: (2021-11-01)

Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles
by: André Cronemberger Andrade, et al.
Published: (2021-04-01)

Synergy of Human Platelet-Derived Extracellular Vesicles with Secretome Proteins Promotes Regenerative Functions
by: Fausto Gueths Gomes, et al.
Published: (2022-01-01)

A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation
by: Martin Wolf, et al.
Published: (2022-04-01)

Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production
by: Michaela Oeller, et al.
Published: (2021-05-01)

Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions
by: Klára Bednářová, et al.
Published: (2020-08-01)

Products of Oxidative Guanine Damage Form Base Pairs with Guanine
by: Katsuhito Kino, et al.
Published: (2020-10-01)

Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine
by: Hiroshi Miyazawa, et al.
Published: (2012-06-01)

Tautomerism of Guanine Analogues
by: Jakub Radek Štoček, et al.
Published: (2020-01-01)

Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression
by: Marie-Theresa Weickert, et al.
Published: (2021-03-01)

Guanine quartets : structure and application /
by: Fritzsche, Wolfgang, et al.
Published: (2013)

Biomineralization and Properties of Guanine Crystals
by: Haoxin Hu, et al.
Published: (2023-08-01)

Guanine crystal formation by bacteria
by: María Elisa Pavan, et al.
Published: (2023-04-01)

Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites
by: Kyung Ah Cheong, et al.
Published: (2020-04-01)

High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch
by: Michal M. Matyjasik, et al.
Published: (2020-05-01)

Endogenous melatonin and oxidatively damaged guanine in DNA
by: Poulsen Henrik E, et al.
Published: (2009-10-01)

Flipping Back of Extrahelical Guanine after Methyl Repair
by: Rajendra Prasad Koirala, et al.
Published: (2022-07-01)

Halogen-Bonded Guanine Base Pairs, Quartets and Ribbons
by: Nicholas J. Thornton, et al.
Published: (2020-09-01)

Gamma irradiation of adenine and guanine adsorbed into hectorite and attapulgite
by: A. Meléndez-López, et al.
Published: (2023-05-01)

Turning on a Chameleon Using Nanocrystals of Biogenic Guanine
by: Catherine E. Housecroft
Published: (2023-06-01)

The Chiral Potential of Phenanthriplatin and Its Influence on Guanine Binding
by: Lippard, Stephen J., et al.
Published: (2015)

Analysis of sequence-selective guanine oxidation by biological agents
by: Margolin, Yelena, 1977-
Published: (2008)

Synthesis, Purification and Crystallization of Guanine-rich RNA Oligonucleotides
by: Pan Baocheng, et al.
Published: (2004-01-01)

Guanine binding to gold nanoparticles through nonbonding interactions
by: Zhang, Xi, et al.
Published: (2014)

Characterization of G-wire formation with guanine-rich sequences
by: Rosal, Katelyn Grace Agdeppa
Published: (2021)

Guanine base stacking in G-quadruplex nucleic acids
by: Lech, Christopher Jacques, et al.
Published: (2013)

Hierarchical Self-Assembly of Noncanonical Guanine Nucleobases on Graphene
by: Nabanita Saikia, et al.
Published: (2017-07-01)

Targeting the guanine-based purinergic system in Alzheimer's disease
by: Débora Lanznaster, et al.
Published: (2017-01-01)

Characterization of oxidative guanine damage and repair in mammalian telomeres.
by: Zhilong Wang, et al.
Published: (2010-05-01)

Hidden triangular grating structures in biogenic guanine platelet
by: Masakazu Iwasaka
Published: (2020-09-01)

Neuromodulatory Effects of Guanine-Based Purines in Health and Disease
by: Carla I. Tasca, et al.
Published: (2018-10-01)

Identification of carboxylesterase genes implicated in temephos resistance in the dengue vector Aedes aegypti.
by: Rodolphe Poupardin, et al.
Published: (2014-03-01)

Heparin and Derivatives for Advanced Cell Therapies
by: Sandra Laner-Plamberger, et al.
Published: (2021-11-01)

Structural and thermodynamic studies on the adenine.guanine mismatch in B-DNA.
by: Leonard, G, et al.
Published: (1990)

Guanine Metal Complexes: Spectroscopic Studies, Dying Performance and as Indicator
by: Asmaa Edrees, et al.
Published: (2024-01-01)

Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
by: Kiran S. Toti, et al.
Published: (2022-04-01)

Structural Polymorphism of Guanine Quadruplex-Containing Regions in Human Promoters
by: Christopher Hennecker, et al.
Published: (2022-12-01)

Analytical and Structural Studies for the Investigation of Oxidative Stress in Guanine Oligonucleotides
by: Györgyi Ferenc, et al.
Published: (2020-07-01)