A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis

A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis

To investigate the correlation between gene mutation and knee osteoarthritis (KOA), a whole-exome sequencing (WES) was applied to analyze blood samples of four KOA patients and two normal subjects in a family. Gene mutations were identified by gene-trapping and high-throughput sequencing analysis ac...

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Bibliographic Details
Main Authors: Yanzhi Ge, Chenfen Zhou, Xiujuan Xiao, Zhijiang Jin, Li Zhou, Zuxiang Chen, Fucun Liu, Qiang Yuan, Guoqing Zhang, Letian Shan, Peijian Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Genetics
Subjects:
KLK6
IL6
knee osteoarthritis
mutation
whole-exome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.784176/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.784176/full

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