MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing

MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing

Abstract: Genome editing provides a potential approach to model de novo leukemogenesis in primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, very low efficiency of translocations and lack of mar...

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Main Authors: Corina Schneidawind, Johan Jeong, Dominik Schneidawind, In-Suk Kim, Jesús Duque-Afonso, Stephen Hon Kit Wong, Masayuki Iwasaki, Erin H. Breese, James L. Zehnder, Matthew Porteus, Michael L. Cleary
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920310272

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http://www.sciencedirect.com/science/article/pii/S2473952920310272

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