Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice

Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice

Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI) outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and neuroinflammation in TBI, but its role in iron-induced post-TBI damage is unclear. We investigated ferroptotic neuronal damage in...

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Bibliographic Details
Main Authors: Hao Cheng, Pengfei Wang, Ning Wang, Wenwen Dong, Ziyuan Chen, Mingzhe Wu, Ziwei Wang, Ziqi Yu, Dawei Guan, Linlin Wang, Rui Zhao
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antioxidants
Subjects:
NRF2
ferroptosis
traumatic brain injury (TBI)
free iron
antioxidant
Online Access:https://www.mdpi.com/2076-3921/12/3/731

Internet

https://www.mdpi.com/2076-3921/12/3/731

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