A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been entrusted with other, although less defined, functions such as the regulation of the angiotensin...

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Bibliographic Details
Main Authors: Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
ERAP1
ERAP2
IRAP
macrophages
Renin-Angiotensin system
Online Access:https://www.mdpi.com/1422-0067/23/9/4961

Internet

https://www.mdpi.com/1422-0067/23/9/4961

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