In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin

In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin

The brain insulin metabolism alteration has been addressed as a pathophysiological factor underlying Alzheimer’s disease (AD). Insulin can be beneficial in AD, but its macro-polypeptide nature negatively influences the chances of reaching the brain. The intranasal (IN) administration of therapeutics...

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Bibliographic Details
Main Authors: Hussein Akel, Ildikó Csóka, Rita Ambrus, Alexandra Bocsik, Ilona Gróf, Mária Mészáros, Anikó Szecskó, Gábor Kozma, Szilvia Veszelka, Mária A. Deli, Zoltán Kónya, Gábor Katona
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
insulin
nose-to-brain delivery
solid lipid nanoparticles
PLGA nanoparticles
chitosan-coating
mucoadhesion
Online Access:https://www.mdpi.com/1422-0067/22/24/13258

Internet

https://www.mdpi.com/1422-0067/22/24/13258

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