Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions

Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions

TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the TARDBP gene) is strongly linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). From the identification of TDP-43 positive aggregates in the brains and spinal cords of ALS/FTD patie...

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Bibliographic Details
Main Authors: Lauren Versluys, Pedro Ervilha Pereira, Nika Schuermans, Boel De Paepe, Jan L. De Bleecker, Elke Bogaert, Bart Dermaut
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neuroscience
Subjects:
TDP-43 proteinopathy
neurons
muscles
neurodegeneration
myopathy
ALS
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.815765/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.815765/full

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