Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models

Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models

Abstract PTEN hamartoma tumour syndrome is characterised by mutations in the human PTEN gene. We performed transcriptomic and proteomic analyses of neural tissues and primary cultures from heterozygous and homozygous Pten-knockout mice. The somatosensory cortex of heterozygous Pten-knockout mice was...

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Bibliographic Details
Main Authors: Stanley K. K. Cheung, Jacinda Kwok, Penelope M. Y. Or, Chi Wai Wong, Bo Feng, Kwong Wai Choy, Raymond C. C. Chang, J. Peter H. Burbach, Alfred S. L. Cheng, Andrew M. Chan
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33869-7

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https://doi.org/10.1038/s41598-023-33869-7

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