Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia

ABSTRACT   The aminoglycosides are highly effective broad-spectrum antimicrobial agents. However, their efficacy is diminished due to enzyme-mediated covalent modification, which reduces affinity of the drug for the target ribosome. One of the most prevalent aminoglycoside resistance enzymes in Gram...

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Bibliografische gegevens
Hoofdauteurs: Georgina Cox, Peter J. Stogios, Alexei Savchenko, Gerard D. Wright
Formaat: Artikel
Taal:English
Gepubliceerd in: American Society for Microbiology 2015-02-01
Reeks:mBio
Online toegang:https://journals.asm.org/doi/10.1128/mBio.02180-14