Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

ObjectiveTo better define the immunopathogenesis of COVID-19, the present study aims to characterize the early immune responses to SARS-CoV-2 infection in household contacts of COVID-19 cases. In particular, innate, T- and B-cell specific responses were evaluated over time.MethodsHousehold contacts...

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Bibliographic Details
Main Authors: Alessandra Aiello, Adriano Grossi, Silvia Meschi, Marcello Meledandri, Valentina Vanini, Linda Petrone, Rita Casetti, Gilda Cuzzi, Andrea Salmi, Anna Maria Altera, Luca Pierelli, Gina Gualano, Tommaso Ascoli Bartoli, Concetta Castilletti, Chiara Agrati, Enrico Girardi, Fabrizio Palmieri, Emanuele Nicastri, Enrico Di Rosa, Delia Goletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
household contacts
COVID-19
SARS-CoV-2
T-cell response
Interferon-alpha (IFN-α)
Interferon-gamma (IFN-γ) release assay (IGRA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.920227/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.920227/full

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