HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD, the authors show that Ku70 phosporylation is regulat...

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Bibliographic Details
Main Authors: Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02671-4

Internet

https://doi.org/10.1038/s42003-021-02671-4

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