IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling

IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling

Rationale: Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in type 2 diabetes mellitus (T2DM). However, the molecular mechanisms underlying these processes especially their inte...

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Bibliographic Details
Main Authors: Ming Yuan, Mengqi Gong, Jinli He, Bingxin Xie, Zhiwei Zhang, Lei Meng, Gary Tse, Yungang Zhao, Qiankun Bao, Yue Zhang, Meng Yuan, Xing Liu, Cunjin Luo, Feng Wang, Guangping Li, Tong Liu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Redox Biology
Subjects:
Endoplasmic reticulum stress
IP3R1–GRP75–VDAC1 complex
Mitochondria
Diabetes
Atrial fibrillation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000611

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http://www.sciencedirect.com/science/article/pii/S2213231722000611

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